I study how tissues are formed and maintained across the animal lifespan, and how tissue structure and function is disrupted by disease. This work cuts across disciplines and spans topics in neuroscience, cancer, gene regulation, and technology development.
Prior to graduate school, I helped to design and test landmark transcriptome and epigenome engineering tools in mammals, enabling optical control and genome-scale screening. During my Ph.D., I studied the development of the human cerebral cortex and explored general physical rules that govern gene regulation. Finally, I transitioned to a role at a startup biotechnology company, where I established and led a machine learning R&D group that has made substantial published contributions to spatial biology data analysis.
I. The Physical Genome
Architecture, constraints, and functional consequences
II. Neural Evolution and Development
Unique genomic and molecular features of the human nervous system and their implications in disease
III. Patient Centric Drug Development
Connecting molecular profiling to real-world patient experiences